Use of lactide polymers for prevention of adhesion

摘要

Use of resorbable physiological films derived from copolymers to prevent postoperative adhesion after surgery is new. The films are prepared from racemic lactide and epsilon -caprolactone, delta -valerolactone, gamma -decalactone or beta -hydroxybutyric acid. Reaction is via the monomers with a molar ratio of lactide:lactone/acid of 90-70:30-10. A metal carboxylate is used as initiator with a ratio of reactants:initiator of 300:1 to more than 1000:1. The reaction is carried out at 130-150 degrees C over 24-96 hours. Preferably the film is made from lactide and glycolide and epsilon -caprolactone or delta -valerolactone. Additives may include antibiotics and a softener (preferably glycerin).