发明名称 |
PROCESS FOR OBTAINING IMAGES AND SPECTRA OF THE EXTRACELLULAR pH BY MAGNETIC RESONANCE WITH EXTRINSINC INDICATORS CONTAINING 1H OR 19F |
摘要 |
<p>The conceptual approach consists in acquiring an MR image or spectrum for any pH-sensitive MR property of molecules non-permeable to the membrane. The chemical shift of a nucleus localized in, or in close proximity to, an ionizable group of a non-permeable molecule, is normally used as a "pH informative resonance" in the extracellular space. Several MR methods (CSIC - Chemical shift selective imaging, or SI - spectroscopic image) can be used to determine the spatial distribution of the "informative resonance", and thereby the extracellular pH distribution within the sample. This information is most useful in clinical conditions such as muscular dystrophy, isquemia, tumoral transformation and metastasis, among others.</p> |
申请公布号 |
EP0977049(A1) |
申请公布日期 |
2000.02.02 |
申请号 |
EP19980904180 |
申请日期 |
1998.02.26 |
申请人 |
UNIVERSIDAD NACIONAL;CONSEJO SUPERIOR DE;THE UNIVERSITY OF ARIZONA;THE JOHNS HOPKINS SCHOOL OF MEDICINE |
发明人 |
BALLESTEROS GARCIA, PALOMA;GIL CONZALEZ, M SOLEDAD;ZADERENKO PARTIDA, PAULA;CERDAN GARCIA-ESTELLER, SEBASTIAN;ALVAREZ PEREZ, JOSE;GILLIES, ROBERT, J.;NATARAJAN, RAGHUNAND;VAN SLUIS, ROBERT;BHUJWALA, ZAVER |
分类号 |
G01R33/28;A61B5/055;A61K49/00;A61K49/06;G01R33/465;G01R33/48;(IPC1-7):G01R33/48 |
主分类号 |
G01R33/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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