| 摘要 |
1,251,750. Prostaglandin analogues. UPJOHN CO. 3 Oct., 1969 [12 Nov., 1968], No. 48802/69. Heading C2C. Novel prostaglandin analogues of the Formulµ I, II and III wherein R 1 is H, C 1-8 alkyl, or a pharmacologically acceptable cation, R 2 and R 3 are H or C 1-8 alkanoyl, with the proviso that when R 3 is alkanoyl R 2 is also alkanoyl, Z is -CH 2 CH 2 -, or cis-CH = CH-, m is 0 or 2, and p is 3 or 5 are prepared by reducing the corresponding compounds of Formulµ I, II and III above in which the groups OR 3 are replaced by carbonyl groups, and, if desired, acylating the resulting hydroxy groups, and esterifying or salifying any of the compounds thus obtained in which R 1 is H. Alternatively, compounds of Formula III above may be obtained by reducing the carbon to carbon double bonds in the corresponding compound of the formula in which X is trans -CH = CH- and Y and Z are -CH 2 CH 2 -, or X is trans-CH=CH-, Y is cis-CH=CH- and Z is -CH 2 CH 2 - or cis-CH = CH-. Therapeutic compositions, suitable for topical or parenteral administration, contain the above novel prostanoic acid derivatives together with pharmaceutically acceptable carriers. The compounds have pressor activity and activity on the central nervous system, inhibit gastric secretion, blood platelet aggregation and thrombus formation. They may also be used for inducing labour in pregnant animals, nasal decongestants, controlling the reproductive cycle in ovulating female mammals, and hypotensive agents. |
