发明名称 |
Nucleic acid encoding an altered telomere repeat binding factor 2 |
摘要 |
The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRFs). Also included are the corresponding nucleic acids that encode the A-TRFs of the present invention, as well as the heterodimers formed by the association of an A-TRF with a TRF. In addition, pharmaceutical compositions containing the A-TRFs for treatment of diseases such as ataxia telangiectasia are also included. Methods of making, purifying and using the A-TRFs of the present invention are described. In addition, drug screening assays to identify drugs that mimic and/or complement the effect of the A-TRFs are presented.
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申请公布号 |
US6020166(A) |
申请公布日期 |
2000.02.01 |
申请号 |
US19990273378 |
申请日期 |
1999.03.22 |
申请人 |
THE ROCKFELLER UNIVERSITY |
发明人 |
DE LANGE, TITIA;VAN STEENSEL, BAS;BIANCHI, ALESSANDRO |
分类号 |
A61K38/00;C07K14/47;C12N1/21;C12N15/12;(IPC1-7):C12P21/02;C12N1/00;C12N5/10;C12N15/63 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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