| 摘要 |
LK6-A derivatives represented by general formula (I) and pharmacologically acceptable salts thereof, which exhibit immunosuppressive, cytostatic and antitumor effects and so on, wherein R<1> is a lower alkanoyl or acryloyl group which may be substituted with, e.g., lower alkoxy, or the like; R<2> is hydrogen, halogeno or the like; R<2'> is hydrogen, or R<2'> together with R<3> forms a bond; R<3> is optionally substituted lower alkanoyl, or R<3> together with R<2'> forms a bond; R<4> and R<5> are each hydrogen, optionally substituted lower alkanoyl or the like; R<6> is hydrogen or the like; and R<7> and R<8> are each hydrogen, optionally substituted lower alkanoyl or the like, with the proviso that LK6-A corresponding to a compound of general formula (I) where R<1> is (E)-methoxyacryloyl; R<2>, R<4>, R<5>, R<6> and R<7> are each hydrogen; R<8> is acetyl; and R<2'> and R<3> together form a bond is excepted. <CHEM> |
