发明名称 |
Method for identifying a presenilinase inhibitor |
摘要 |
The present invention pertains to methods for identifying a substance capable of reducing or eliminating the activity of the presenilinase wherein a cell or a cell line is cultivated expressing said presenilinase activity and a fusion-protein comprising the full-length presenilin 1 or presenilin 2 and a reporter is measured. The invention is furthermore concerned with substances identifiable with said methods, pharmaceutical compositions comprising said substances and the use of said substances in the manufacture of a medicament for the treatment of neurodegenerative diseases or Alzheimer's disease. |
申请公布号 |
AU5034099(A) |
申请公布日期 |
2000.02.01 |
申请号 |
AU19990050340 |
申请日期 |
1999.07.08 |
申请人 |
BOEHRINGER INGELHEIM PHARMA KG |
发明人 |
KATJA FECHTELER;CHRISTIAN HAASS;HARALD STEINER |
分类号 |
G01N33/50;A01K67/027;A61K31/711;A61K45/00;A61K48/00;A61P25/28;A61P43/00;C07K14/47;C12N9/99;C12N15/09;C12Q1/02;G01N33/15;G01N33/573;G01N33/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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