摘要 |
This invention relates to compounds of formula (1) wherein B is optionally substituted aryl; R<SUP>1 </SUP>and R<SUP>2 </SUP>are the same or different and are independently selected from hydrogen or C<SUB>1-3 </SUB>alkyl; n is 1 or 2, preferably n is 1; m is 0 or 1; R<SUP>3 </SUP>is hydrogen or acyl; R<SUP>4 </SUP>and R<SUP>5 </SUP>are the same or different and are independently selected from amino, alkylamino, dialkylamino, arylamino and C<SUB>2</SUB>-C<SUB>8 </SUB>cycloalkylamino; X and Y are independently selected from C, H or N provided at least one of X and Y is N; and salts thereof, solvates thereof, pharmaceutically acceptable derivatives thereof, prodrugs thereof, tautomers thereof and/or isomers thereof; and processes for their preparation and methods of treatment, pharmaceutical formulations and uses involving them. |