Nucleic acids encoding the hypoxia inducible factor-1

摘要

The purified and characterization of hypoxia-inducible factor 1 (HIF-1) is described. HIF-1 is composed of subunits HIF-1a and HIF-1 beta . Purified HIF-1a polypeptide, its amino acid sequence and polynucleotide sequence are provided. A HIF-1 alpha variant that dimerizes to HIF-1 beta producing a nonfunctional HIF-1 complex is described. Methods for the prevention and treatment of hypoxia-related disorders are provided.