| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new sulfur-containing heterocyclic compound having antifungal actions. SOLUTION: This compound is represented by formula I (R1 is a sulfur- containing heterocyclic ring which may have a halogen; R2 is a 1-4C alkyl; R3 is a hydrocarbon having >=6πelectrons), e.g. trans-N-(6,6-dimethyl-2-hepten-4- ynyl)-N-methyl-2-(3-chloro-3-thienyl)-2-thienyl)-2-propenylamine represented by formula II. The compound represented by formula I is obtained by carrying out the Wittig reaction of a compound represented by formula III with methyltriphenylphosphonium bromide and butyl-lithium. A compound group represented by formula IV, in which Cl is especially preferred as the halogen, is especially preferred in the compound represented by formula I. When the above compound is used as an antifungal agent, the daily dose thereof for an adult is preferably 1-10,000 mg for, e.g. oral administration or parenteral injection and an adequate amount of a skin preparation for external use and a pessary containing 0.1-10 wt.% of the compound is preferably applied and administered.
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