| 发明名称 |
DNA ENCODING PRECURSOR OF INTERLEUKIN-1-g(b) CONVERTING ENZYME-RELATED CYSTEINE PROTEINASE III (ICE rel?-III) |
| 摘要 |
<p>A complementary DNA (cDNA) encoding full length form of ICErel-III is identified, sequenced and isolated. The cDNA is cloned into expression vectors for expression in recombinant hosts. The cDNA is useful to produce recombinant full length ICErel-III. The cDNA and the recombinant ICErel-III protein derived therefrom are useful in diagnostic kits, laboratory reagents and assays. The cDNA and the recombinant ICErel-III protein may be used to identify compounds that affect ICErel-III function, inflammation and cell apoptosis. ICErel-III function, inflammation and cell apoptosis may also be modulated by ICErel-III antisense or gene therapy.</p> |
| 申请公布号 |
GR3031474(T3) |
申请公布日期 |
2000.01.31 |
| 申请号 |
GR19990402565T |
申请日期 |
1999.10.08 |
| 申请人 |
MERCK FROSST CANADA INC. |
发明人 |
NICHOLSON, DONALD W.;ALI, AMBEREEN;MUNDAY, NEIL A.;VAILLANCOURT, JOHN P. |
| 分类号 |
G01N33/53;A61K38/00;A61K38/46;A61K48/00;A61P9/00;A61P25/00;A61P25/28;A61P31/04;A61P35/00;A61P37/00;A61P43/00;C07H21/04;C07K16/40;C12N1/19;C12N1/21;C12N5/10;C12N9/64;C12N15/09;C12N15/57;C12Q1/37;C12Q1/68;C12R1/91;(IPC1-7):C12N15/57;C12N15/11;G01N33/573 |
主分类号 |
G01N33/53 |
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