Quinoxalinediones, preparation and pharmaceutical compositions thereof

摘要

he compounds of formula (I) and the pharmaceutically acceptable salts thereof wherein: R is an optionally substituted, optionally benzo-fused 5-membered ring heteroaryl group containing 3 or 4 nitrogen heteroatoms which is linked to the quinoxalinedione ring by a ring carbon or nitrogen atom or R is an optionally substituted, optionally benzo-fused 6-membered ring heteroaryl group containing from 1 to 3 nitrogen heteroatoms which is linked to the quinoxalinedione ring by a ring carbon atom; R1 and R2 are independently H, fluoro, chloro, bromo, alkyl or haloalkyl; R3 and R4 are independently H or alkyl or together are alkylene and p is 0, 1 or 2 are claimed. A pharmaceutical composition containing a compound of formula I useful as a NMDA receptor antagonist for treating acute neurodegenerative and chronic neurological disorders is also claimed.