| 摘要 |
n indolocarbazole ester of formula Q-L-C(O)-A is claimed wherein: A is a solublizing group selected from amino acid residue, dipeptide residue, -(CH2)m-Z, -(CH2)m-C(O)-NH-(CH2)m-Z, -(CH2)m-C(O)-NH-Z, -(CH2)m-Z-(CH2)m-Z, branched -(CH2)n-CH-{(CH2)m-Z}2, -(CH2)m-Z-{(CH2)m-Z}2-(CH2)n-A1, -(CH2)n-heteroaryl and -NH-(CH2)m-N-(CH3)2; n is 0 to 5; m is 1-6; Z is a basic group, -C(=NH)NH2, cyclic amidine, -NHC(NH2)=NR11 (with R11 being H or alkyl), cyclic guanidine and an acidic group; A1 is an optionally -(CH2)n-Z substituted aryl or heteroaryl; L is O and Q is an indolocarbazole as defined in the specification limited by the provisos given in the specification. The above compound is useful in treating a pathological condition of the prostate.
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