发明名称 |
Arthritogenic peptide, DNAJ, isolated from bacterial peptides and used in vaccine compositions for treating rheumatoid arthritis |
摘要 |
Method for the production of a vaccine composition useful in inducing T-cell mediated immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis. Each vaccine composition provides antigenic dnaJp1 peptide (by including the peptide or a polynucleotide, which encodes the peptide) and, optionally, other peptide fragments of the microbial dnaJ protein and/or human homologs thereof. Also described is a method for the screening of candidates by: (i) measuring cellular and humoral immune responses to an arthritogenic peptide (ii) detecting the rheumatoid arthritis susceptibility sequence in the individual's HLA DR antigens |
申请公布号 |
NZ331989(A) |
申请公布日期 |
2000.01.28 |
申请号 |
NZ19970331989 |
申请日期 |
1997.02.20 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CARSON, DENNIS A |
分类号 |
A61K38/00;A61K31/00;A61K35/74;A61K38/22;A61K39/00;A61K39/395;A61K39/40;A61K45/00;A61K48/00;A61P19/00;A61P19/02;A61P29/00;A61P37/00;C07K14/245;C07K14/47;C07K14/74;C07K16/04;C07K16/12;C12N15/09;C12N15/31;G01N33/53;G01N33/564;(IPC1-7):C12N15/31;A61K39/108 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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