| 摘要 |
he compound of formula I or its salts and quaternary ammonium salts formed with acyclic or cyclic tertiary amines and it solvates wherein: R1 is -T-CN, -C(NH2)=NOH, -C(=NOH)-NH-(CH2)rNR5R6, -T-C(NR12R13)=NR14, -C(NH2)=NO(CH2)rNR5R6, -T-CONRaRb, -T-CONR7RC, ORd, -T-N(R7)CORe, -SO2NRaRb, -T-N(R7)-SO2R'7 or -T-NR27R28; R2 and R3 independently are H, alkyl, cycloalkylmethyl, cycloalkyl, halo, nitro, trifluoromethyl, -OR4, -NR5R6, 1-pyrrolyl, cyano or carbamoyl or R2 and R3 together form a trimethylene, tetramethylene or pentamethylene group; R4 is H, alkyl, alkenyl, cycloalkylene, cycloalkylmethyl, alkoxyalkylene or benzyl and the rest of the variables are as defined in the specification is claimed. the compounds of formula I have an affinity to human neurotensin receptors.
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