Tricyclic compounds useful for inhibition of g-protein function and for treatment of prolifeative diseases

摘要

he present invention relates to tricyclic compounds of formula 1 for inhibition of abnormal growth cells where: A and B are independently selected from H, halo, or C1-6 alkyl Z is N or CH W is CH, CH2, O or S wherein the dotted line to W represents a double bond which is present when W is CH X is C, CH or N, wherein the dotted line connecting X to the tricyclic ring system represents a double bond when X is C R2 is selected from H, -C(O)OR6- C(O)NR6R7, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, substituted C1-8 alkyl and others R1 is selected from the following groups 1a-d or disulphide dimers thereof or Group 2, Group 3a or 3b, and other groups as defined in the specification