| 摘要 |
rovided are pyrimido[4,5-b]indoles of the formula shown and lactams of formula (XIII) as shown wherein: each of R2-1 and R4-1 is H, or an optionally substituted alkyl; and each of R2-2 and R4-1 is H, or an optionally substituted alkyl; or R2-1 and R2-2 are taken together with the nitrogen atom to form a heterocyclic ring; and R7 is an optionally substituted pyrindin -2-, 3-, or 4-yl-(CH2)0-6, -(CH2)0-6CO2R7-2, -(CH2)0-6CON(R7-3)2, -(CH2)0-6CONR7-4R7-5 or -(CH2)0-6SOR7-2, where in R7-2, R7-3, R7-4 and R7-5 are defined in the specification. Such compounds are disclosed as having numerous pharmaceutical applications
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