| 摘要 |
Methods and compositions for the treatment of positive and negative symptoms of schizophrenia and tardive dyskinesia are provided. Compositions include 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and its analogs, and/or pyridinium ions thereof, administered in amounts sufficient to reduce dopamine levels in subcortical areas of the brain without causing symptoms of Parkinson's disease. One course of treatment can result in permanent or long-term amelioration of symptoms.
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