MYOTILIN, AN ACTIN-ORGANIZING PROTEIN

摘要

The present invention concerns a novel cytoskeletal protein, myotilin, which contains Ig-like domains homologous to a giant sarcomeric structural protein titin. Myotilin is expressed in skeletal and cardiac muscles, it colocalizes with .alpha.-actinin in the sarcomeric I-bands and directly interacts with .alpha.-actinin. Expression of myotilin in mammalian non-muscle cells and in yeast causes reorganization of actin into thick F-actin bundles and inhibits growth of yeast cells.