ETHYLENE-VINYL ACETATE COPOLYMER-BASED SELF-GUMMING TRANSDERMAL MATRIX SYSTEM FOR INTRODUCING ESTROGEN AND/OR PROESTROGEN INTO BODY AND METHOD FOR PREPARATION THEREOF

摘要

FIELD: medicinal technics. SUBSTANCE: system contains carrier and self-gumming matrix. The latter contains, wt parts: ethylene-vinyl acetate copolymer, 40-60; cellulose material, 5-20; at least one compound selected from group including crotamitone, 2-pyrrolidone N-substituted by C1-C15-alkyl, cyclohexyl, or 2-hydroxyethyl, aliphatic C12-C20-alcohols, 35-55; and hormone containing estrogen components, proestrogen components, or their mixtures, 0.01-7. Invention also provides method of preparing such system. EFFECT: enhanced release of hormone. 12 cl, 4 dwg, 4 tbl, 16 ex