发明名称 |
USE OF 11-(3-DIMETHYLAMINOPROPYLIDENE)-6,11-DIHYDRODIBENZ[B,E]OXEPIN-2-ACETIC ACID FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING NON-ALLERGIC OPHTHALMIC INFLAMMATORY DISORDERS AND FOR THE PREVENTION OF OCULAR NEOVASCULARIZATION |
摘要 |
Ophthalmic formulations containing as an active ingredient 11-(3-dimethylaminopropylidene) -6,11-dihydrodibenz¢b,e!oxepin-2-acetic acid or a pharmaceutically acceptable salt thereof are useful for inhibiting cytokine release (e.g., IL-6 and IL-8) from human ocular cells. Such formulations can be used to treat or prevent ocular neovascularization and non-allergic inflammatory disorders such as dry-eye, keratitis, blepharitis, uveitis and inflammation related to infection.
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申请公布号 |
CA2306393(A1) |
申请公布日期 |
2000.01.27 |
申请号 |
CA19992306393 |
申请日期 |
1999.06.15 |
申请人 |
ALCON LABORATORIES, INC. |
发明人 |
GAMACHE, DANIEL A.;WEIMER, LORI K.;YANNI, JOHN M. |
分类号 |
C07D313/12;A61K;A61K31/335;A61P27/02;A61P43/00;(IPC1-7):A61K31/335 |
主分类号 |
C07D313/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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