发明名称 |
POLYSACCHARIDE VACCINE FOR STAPHYLOCOCCAL INFECTIONS |
摘要 |
The invention relates to compositions of the capsular polysaccharide/adhesin (PS/A) of staphylococci. The PS/A may be isolated or synthesized and include s various modifications to the structure of native PS/A based on the chemical characterization of PS/A. The invention also relates to the use of the PS/A as a vaccine for inducing active immunity to infections caused by Staphylococcu s aureus, S. epidermidis, other related coagulase-negative staphylococci and organisms carrying the ica (intracellular adhesin) locus, and to the use of antibodies directed to PS/A for inducing passive immunity to the same class of infections.
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申请公布号 |
CA2333931(A1) |
申请公布日期 |
2000.01.27 |
申请号 |
CA19992333931 |
申请日期 |
1999.07.15 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
MCKENNEY, DAVID;WANG, YING;PIER, GERALD B. |
分类号 |
A61K31/702;A61K31/715;A61K39/085;A61P31/04;C07H3/06;C08B37/00;(IPC1-7):A61K39/085;C07H5/06;C07H11/00;C07H13/12 |
主分类号 |
A61K31/702 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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