METHOD FOR IDENTIFYING MUTANTS AND MOLECULES

摘要

A method for breeding mutagenized mice that permits detection of genetic loc i that can modify a known index phenotype involves crossing a mutagenized founder strain and a second strain of mice carrying an allele at a locus tha t confers the index phenotype. In the test generation, clusters of individuals are observed to deviate from the typical phenotype. The genetic material and molecules encoded thereby can be obtained using available methods. Improved and compact methods are also disclosed.