| 发明名称 |
WATER-SOLUBLE DRUGS AND METHODS FOR THEIR PRODUCTION |
| 摘要 |
the present invention provides water-soluble drugs, in particular, water- soluble analogues of geldanamycin, and compositions comprising the same. Thi s invention also provides a method of rendering water-insoluble drugs soluble in water through derivatization with a bifunctional linking molecule and subsequent conjugation to a polar moiety through a thio ether. The present invention further provides a method of treating cancer in a mammal.
|
| 申请公布号 |
CA2338000(A1) |
申请公布日期 |
2000.01.27 |
| 申请号 |
CA19992338000 |
申请日期 |
1999.07.15 |
| 申请人 |
THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT O F HEALTH AND HUMAN SERVICES |
发明人 |
MANDLER, RAYA;ALVARADO-LINDNER, ADA BELINDA;UPADHYAY, KAYE B. DILLAH;NEWMAN, DAVID J.;HO, DAVID K. |
| 分类号 |
C07D225/06;A61K31/395;A61K45/00;A61K47/48;A61P35/00;C07D207/40;C07D207/416;C07D225/02;C07D403/12;(IPC1-7):A61K47/48 |
主分类号 |
C07D225/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
