Cholinesterase activator

摘要

PCT No. PCT/JP95/00229 Sec. 371 Date Aug. 15, 1996 Sec. 102(e) Date Aug. 15, 1996 PCT Filed Feb. 17, 1995 PCT Pub. No. WO95/22326 PCT Pub. Date Aug. 24, 1995The invention relates to a cholinesterase activator comprising, as an active ingredient, a compound represented by the following general formula (I): wherein A means a group such as a phenyl group or indanyl group, B denotes a group such as a prolyl group or thioprolyl group, and m stands for an integer of 0-5. The cholinesterase activator according to the invention has a strongly activating action on cholinesterase, in particular, a selectively activating action on peripheral cholinesterase and is also high in safety. It is hence useful as an agent for preventing and treating the side effects of central cholinesterase inhibitors, in particular, hepatopathy, and an agent for preventing and treating the side effects of various medicines manifested on the basis of a cholinesterase-inhibiting action.