发明名称 HEAT SHOCK PROTEIN INDUCER
摘要 PROBLEM TO BE SOLVED: To obtain the subject medicine useful for treating and improving cerebral nerve disease, cardiovascular disease, gastrointestinal disease, malignant tumor, infectious disease, organ transplantation, renal insufficiency, hepatic insufficiency, etc., by including a specific cholesteryl glucopyranoside as an active ingredient. SOLUTION: TIG-3 cell, a human fibroblast strain is cultured at 37 deg.C, is provided with heat stress by adding a medium at 42 deg.C and cultibated at 42 deg.C for a fixed time. A lipid is extracted by using cold methanol and then a chloroform/methanol mixed solution. A part corresponding to a steryl glycoside derived from a slime mold is scratched off and extracted by using silica gel 60HPTLC plate and then purified by high-performance liquid chromatography to give chloesteryl glycopyranoside of the formula (Me is methyl). Then the compound as an active ingredient is pharmaceutically manufactured to give a heat shock protein inducer useful for treating cerebral nerve disease, cardiovascular disease, gastrointestinal disease, malignant tumor, infectious disease, multiple sclerosis, etc.
申请公布号 JP2000026495(A) 申请公布日期 2000.01.25
申请号 JP19980195278 申请日期 1998.07.10
申请人 EISAI CO LTD 发明人 MUROFUSHI KIMIKO;KOBAYASHI SUSUMU;YAMATSU ISAO
分类号 C07J9/00;A61K31/704;A61P1/00;A61P1/04;A61P1/16;A61P3/08;A61P9/00;A61P11/00;A61P13/02;A61P15/00;A61P25/00;A61P25/28;A61P27/02;A61P31/00;A61P35/00;A61P43/00;(IPC1-7):C07J9/00;A61K31/705 主分类号 C07J9/00
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