Peptide, peptide analog and amino acid analog protease inhibitors

摘要

Methods of use of compounds and compounds for the treatment of disorders characterized by the cerebral deposition of amyloid are provided. Among the compounds are those of formulae (I), (II) and (III): in which R1 is preferably 2-methyl propene, 2-butene, norleucine; R2, R4, and R8 are each independently methyl or ethyl; R3 is preferably iso-butyl or phenyl; R5 is preferably iso-butyl; R6 is H or methyl; R7-(Q)n is preferably benzyloxycarbonyl or acetyl; Q is preferably -C(O)-; RB is preferbly iso-butyl; RA=-(T)m-(D)m-R1, is which T is preferably oxygen or carbon, and D is preferably a mono-unsaturated C3-4 alkenyl being more preferred; and X is an alcohol, particularly a secondary alcohol.