| 摘要 |
PURPOSE: The diaza-spiro£3.5| nonan derivative is provided to be the agent or the antagonist of the orphanin FQ(OFQ) receptor, and to have useful treatment for a disease related with this receptor. CONSTITUTION: It is about the compound of the chemical formula 1, the racemic compound and the enantiomer corresponding to these or the acid added salt to be able to permit by chemical. R1 is the C6-12-cycloakyl selectively replaced to the low-grade alkyl or the C(O)O low-grade alkyl and the indan-1-il or the indan-2-il selectively replaced to the low-grade alkyl; R2 is =O or the hydrogen; R3 is the hydrogen, the isoindolyl-1.3-dion, the low-grade alkyl, the amiNO, the benzene oxy; R4 is the hydrogen or the -CH2OR5; R5 is the hydrogen or the low-grade alkyl; A is the cyclohexyl of phenyl selectively replaced to the low-grade alkyl, the halogen, or the alkoxy. |
