| 摘要 |
Novel oligonucleotides are provided having cationic internucleoside linkages. The cationic internucleoside linkage has the structure wherein W, X, Y, Z, R1, R2, and R3 are as defined herein, P* represents an asymmetric phosphorus atom capable of existing in two distinct stereoisomeric configurations, and further wherein the internucleoside linkage is stereouniform. Certain of these oligonucleotides may have alternating anionic and cationic internucleoside linkages, which are not necessarily stereouniform. A method for synthesizing the compounds are provided as well, as are methods for using the compounds, e.g., as antisense molecules and in nucleic acid hybridization assays.
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