发明名称 |
3-EPI vitamin D2 compounds and uses thereof |
摘要 |
Novel 3-epi vitamin D2 compounds having the orientation of the substituent attached to the carbon at position 3 of the A-ring of vitamin D2 inverted from a beta ( beta ) to an alpha ( alpha ) configuration are described. These compounds were first identified as metabolites of vitamin D2 produced via a tissue-specific metabolic pathway which catalyzes the 3- beta -hydroxy epimerization of vitamin D2 compounds. The 3-epi vitamin D2 compounds of the present invention can be used as substitutes for natural and synthetic vitamin D.
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申请公布号 |
US6017908(A) |
申请公布日期 |
2000.01.25 |
申请号 |
US19980079838 |
申请日期 |
1998.05.15 |
申请人 |
WOMEN AND INFANTS HOSPITAL |
发明人 |
REDDY, SATAYANARAYANA G. |
分类号 |
A61K31/59;A61K31/592;A61P3/00;A61P5/18;A61P13/12;A61P19/08;A61P19/10;A61P43/00;C07C401/00;(IPC1-7):A01N45/00 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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