THERAPEUTIC COMBINATION CONTAINING SELECTIVE ESTROGEN RECEPTOR MODULATOR AND PROSTAGLANDIN E2

摘要

PROBLEM TO BE SOLVED: To obtain a therapeutic combination containing a selective estrogen receptor modulator and prostaglandin E2. SOLUTION: This pharmaceutical composition comprises a combination of (a) a first compound which is (-)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)- phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol or its pharmaceutically acceptable salt with (b) a second compound that is PGE2 or its pharmaceutically acceptable salt.