发明名称 |
Partial agonists of the strychnine insensitive glycine modulatory site of the N-methyl-D-aspartate receptor complex as neuropsychopharmacological agents |
摘要 |
A method is disclosed for the treatment of neuropsychopharmacological disorders which are associated with or result from excessive activation of the N-methyl-D-aspartate receptor complex, which method comprises administering an effective neuropsychopharmacological disorder-treating amount of a compound possessing partial agonist properties for the strychnine insensitive glycine modulatory sites of N-methyl-D-aspartate receptors. Exemplary of partial agonists which are useful in the method of the invention are 1-aminocyclopropanecarboxylic acid, and associated derivates thereof. Novel injectable pharmaceutical compositions are also disclosed.
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申请公布号 |
US6017957(A) |
申请公布日期 |
2000.01.25 |
申请号 |
US19890390745 |
申请日期 |
1989.08.08 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
SKOLNICK, PHIL;LEWIN, ANITA;MARVIZON, JUAN-CARLOS;MONN, JAMES;RICE, KENNER |
分类号 |
A61K31/195;A61K31/215;A61K45/00;A61P25/00;A61P25/18;A61P25/20;A61P25/28;(IPC1-7):A61K31/215 |
主分类号 |
A61K31/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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