摘要 |
The invention relates to pharmaceutical compositions of transferrin and the preparation of such compositions. The invention relates, in particular, to pharmaceutical compositions of apotransferrin, i.e. the iron-free form of transferrin, which exhibit at least 90% of the theoretical iron-binding capacity of iron-free transferrin, which contain less than 3% transferrin dimers, which do not contain demonstrable quantities of transferrin polymers or aggregates and whose iron saturation level is less than 2%. The pharmaceutical apotransferrin composition according to the invention efficiently binds that iron which is not bound to transferrin into an innocuous form when it is administered to patients by intravenous injection or infusion. The pharmaceutical composition according to the invention does not contain any viruses, denatured forms of transferrin or other harmful components. |