发明名称 |
Methods and compositions for NMR structure determinations. |
摘要 |
This invention is concerned with determining the three-dimensional structure of biological macromolecules such as proteins. In particular, it is concerned with methods for rapidly determining protein structure by NMR, by providing methods for simplifying NMR spectra using labeled proteins prepared from specifically isotopically labeled amino acids having at least two isotopes of 13C, 15N and 2H in the backbone, and methods for making these labeled proteins, e.g., by cultivation of a microbial culture containing said labeled amino acids. |
申请公布号 |
ZA9807975(B) |
申请公布日期 |
2000.01.21 |
申请号 |
ZA19980007975 |
申请日期 |
1998.09.01 |
申请人 |
MARTEK BIOSCIENCES CORPORATION |
发明人 |
FRANK ELBERT ANDERSON III;PHILIP EDWARD COUGHLIN;CHARLES TOBIAS WELLER;JONATHAN MILES BROWN;STEVEN WILLIAM HOMANS;CARRIE ANN ZIMMERMAN-WILSON |
分类号 |
G01N24/08;C07B43/06;C07B59/00;C07K14/00;C07K14/59;C12N1/20;C12N5/00;C12N5/02;C12N5/06;C12P21/00;C12P21/02;G01N33/68;G01R33/465 |
主分类号 |
G01N24/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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