CYTOKINE PRODUCTION AND TYROSINE KINASE INHIBITORS

摘要

A compound of formula (I), wherein alpha X is =O, =N-OR<6>, beta NHR or beta OH wherein R<6> is H or C1-C6 alkyl, bond a is oriented gamma or delta and R is H, C1-C6 alkyl which is unsubstituted or substituted by C6-C10 aryl, or C3-C6 cycloalkyl; epsilon is a bond when zeta and eta are not bonds or, when X is =O, zeta and eta are both bonds and epsilon is not a bond; R<1> and R<2>, which are the same or different, are H or a halogen; R<3> and R<4>, which are the same or different, are H, C1-C6 alkyl, C3-C6 cycloalkyl, a heterocyclic group or an aromatic group; bond e is oriented gamma or delta ; and R<5> is C1-C6 alkyl; or formula (Ib), or formula (II), or formula (III), has activity as a cytokine production inhibitor and an inhibitor of tyrosine kinase. A process for producing some of the compounds from a fungal strain, processes for producing synthetic analogues from these compounds and the use of the compounds in treating immunoinflammatory and cancerous conditions are also described.