AMINOIMINOQUINONE AND AMINOQUININE ALKALOID COMPOUNDS AS CAPASE INHIBITORS

摘要

The subject application concerns novel compounds of structural formula (I) wherein R<1> is NH or O; R<2> is OZ; R<3> is OZ; R<4> is H or R; R<5> is NH2, NR2, or OZ; and R<6> is H or X; wherein Z is selected from the group consisting of H, R, COR, mesyl, tosyl, glutamyl, succinyl, and malonyl; R is selected from the group consisting of C1 to C8 alkyl, phenyl, and benzyl; and X is C1, Br, or I, with useful biological properties. For example, theses compounds can be used as anti-inflammatory, anti-proliferative, immunomodulatory, and/or neuroprotective agents. Specific examples of the compounds of the subject invention include Secobatzelline A and Secobatzelline B, which can be isolated from marine sponges.