发明名称 |
CANCER TREATMENT METHODS USING ANTIBODIES TO AMINOPHOSPHOLIPIDS |
摘要 |
<p>Disclosed are the surprising discoveries that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are stable and specific markers accessible on the luminal surface of tumor blood vessels, and that t he administration of an anti-aminophospholipid antibody alone is sufficient to induce thrombosis, tumor necrosis and tumor regression in vivo. This inventi on therefore provides anti-aminophospholipid antibody-based methods and compositions for use in the specific destruction of tumor blood vessels and in the treatment of solid tumors. Although various antibody conjugates and combinations are thus provided, the use of naked, or unconjugated, anti- phosphatidylserine antibodies is a particularly important aspect of the invention, due to simplicity and effectiveness of the approach.</p> |
申请公布号 |
CA2333147(A1) |
申请公布日期 |
2000.01.20 |
申请号 |
CA19992333147 |
申请日期 |
1999.07.12 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
THORPE, PHILIP E.;RAN, SOPHIA |
分类号 |
A01K67/027;A61K38/00;A61K39/395;A61K45/00;A61K47/48;A61K49/04;A61K49/08;A61K51/10;A61P35/00;C07K16/00;C07K16/18;C07K16/28;(IPC1-7):A61K39/395 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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