发明名称 |
PRION PROTEIN AND USES THEREOF |
摘要 |
The present invention provides for a novel method of detecting the prion protein and variants thereof which utilizes specific amino acid binding sequences. Specifically, the present invention provides a method of detecting prion proteins, as well as isolating prion proteins, using an agent that binds to the amino acid sequence Gln-Pro-His of prion proteins. Further provided by the present invention is a method of diagnosing prion diseases in a subject using an agent that binds to the amino acid sequence Gln-Pro-His of prion proteins. Also provided are methods of treating and preventing prion diseases in a subject by administering an agent that binds to the amino acid sequence Gln-Pro-His of prion proteins. Finally, a method of inhibiting the dissemination of prion diseases through ingestion or exposure to liquid or solid substances by treating of the liquid or solid substance with biotin is provided herein.
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申请公布号 |
WO0002575(A1) |
申请公布日期 |
2000.01.20 |
申请号 |
WO1999US15288 |
申请日期 |
1999.07.07 |
申请人 |
V.I. TECHNOLOGIES, INC. |
发明人 |
HAMMOND, DAVID, J.;MEDINA, EMMA, L. |
分类号 |
A61K38/00;C07K14/47;G01N33/68;(IPC1-7):A61K38/00;A61K48/00;C07K1/00;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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