| 摘要 |
The invention relates to a topical plaster with an active agent in the form of a non-steroidal antirheumatic agent. The plaster consists of a back layer that is inert in relation to the active agent, a self-adhesive matrix layer based on a polyacrylate adhesive, containing the active agent, and a protective film which is removed before use. The invention is characterised in that a) the non-steroidal antirheumatic agent has a free carboxyl group; b) the matrix containing the active agent consists of a polyacrylate adhesive which is cross-linked with multivalent metal ions and which has free carboxyl groups, and is free of hydroxyl groups; c) the matrix contains a fatty acid which serves as a plasticizer and a permeation accelerator; and d) the back layer consists of a material which is elastic in at least one direction. |
