METHOD FOR THE PRODUCTION OF RECOMBINANT PEPTIDES WITH A LOW AMOUNT OF TRISULFIDES

摘要

The invention relates to a method for the production of recombinant peptides with a low amount of trisulfides which is characterized by the addition of a metal salt during or after the fermentation step and to a method for reduction of the amount of trisulfides in the production of recombinant peptides, characterized by the addition of a metal salt during or after fermentation. The peptide is preferably human growth hormone and the salt preferably a potassium or sodium phosphate.