| 摘要 |
FIELD: synthesis of biologically- active compounds. SUBSTANCE: invention provides new erythromycin derivatives depicted by general formula I: <EMI ID=0.1 HE=61 WI=43 TI=CHI> (I), in which R and R1 are hydroxyl or O-C2-1010-acyl; R2 methyl; R3 is ether radical -(CH2)mR4 with m=4 or radical -N-(CH2)qR4 with q= 3; and R4 is optionally phenyl-substituted heterocyclic mono- or polycyclic radical such as imidazolyl, pyridyl, thiazolyl, quinolinyl, or 3H-imidazo[4,5-b] pyridyl or their additive salts with acids. Compounds I exhibit important antibiotic properties. EFFECT: enlarged choice of antibiotics. 13 cl, 1 tbl, 10 ex
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