IMPROVED PROCESS FOR SYNTHESIZING CARBAPENEM INTERMEDIATES

摘要

The invention describes an improved process for synthesizing 1-.beta.-methyl -2- hydroxymethyl substituted carbapenems as key intermediates for the synthesis of anti-MRSA carbapenem antibiotics. The synthesis eliminates the use of BU3SnCH2OH and HMPA, which are toxic substances and not amenable to industri al scale production. The novel intermediates are also within the scope of this invention.