ANTIBODY AGAINST PROTEIN TYROSINE PHOSPHATASE INTRACELLULAR DOMAINS

摘要

An antibody specific to intracellular domains of at least two protein tyrosine phosphatases; a process for preparing the same; and cells producing the above antibody. This antibody, which has specificities to intracellular domains of both of phosphatase subunits LAR and CD45, is useful in analyzing and quantitating PTPs, identifying and detecting a novel PTP, acquiring a novel phosphatase by cloning, etc., as well as developing a diagnostic method useful in insulin resistance and NIDDM, preventing, treating (curing, etc.) and diagnosing various symptoms of syndrome X based on insulin resistance, and preventing and diagnosing the onset of arteriosclerosis and heart diseases.