| 摘要 |
<p>Herein it is shown that hemoproteins (e.g.Ascaris hemoglobin, myoglobin, flavohemoglobins) have NO-consuming and deoxygenase activities. The invention provides a method of reducing the concentration of oxygen and/or nitric oxide in a mammal. The method of the invention comprises administering a therapeutically effective amount of a hemoprotein having NO-activated deoxygenase activity or an enzymatically active fragment thereof to a mammal. The method can be used to treat a mammal having pathologically proliferating cells, such as a tumor. The invention further provides a method of treating a mammal infected with Ascaris sp., comprising administering to said mammal a therapeutically effective amount of an inhibitor of NO-synthase. The NO-consuming activity of a hemeprotein (e.g. flavohemoglobin) can be used in a treatment where constriction of blood vessels is desirabel, or where it is otherwise desirable to reduce NO concentration, as inflammation.</p> |
