发明名称 |
Insertional mutations in mycobacteria |
摘要 |
<p>A mutated mycobacterium selected from the class consisting of mutated M.bovis-BCG, mutated M.tuberculosis, and mutated M.leprae. The mutation of M.bovis-BCG, M.tuberculosis, or M.leprae is preferably effected through an insertional mutation of a mycobacterial gene. The insertional mutagenesis may be effected, for example, through illegitimate recombination or by a mycobacterial transposon. Such mutated mycobacteria may then be transformed with an expression vector(s) containing a complement gene to the gene which is mutated, and preferably also including a heterologous gene.</p> |
申请公布号 |
EP0972839(A1) |
申请公布日期 |
2000.01.19 |
申请号 |
EP19990110251 |
申请日期 |
1992.06.02 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY |
发明人 |
JACOBS, WILLIAM R.;BLOOM, BARRY;KALPANA, GANJAM V.;CIRILLO, JEFFREY D. |
分类号 |
A61K39/04;A61K39/00;A61P31/00;A61P31/04;A61P31/06;C07K14/35;C12N1/21;C12N15/09;C12N15/74;C12R1/32;(IPC1-7):C12N15/74 |
主分类号 |
A61K39/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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