This invention relates to synthetic oligonucleotides that are useful for antisense based therapeutic applications. The synthetic oligonucleotides of this invention have modifications in the sugar phosphate backbone for improved antisense properties.
申请公布号
US6015886(A)
申请公布日期
2000.01.18
申请号
US19970795926
申请日期
1997.02.05
申请人
CHEMGENES CORPORATION;OLIGOS ETC., INC.
发明人
DALE, RODERIC M. K.;ARROW, AMY;SRIVASTAVA, SURESH C.;RAZA, SYED K.
