ELASTASE INHIBITORY POLYPEPTIDE AND PROCESS FOR PRODUCTION THEREOF BY RECOMBINANT GENE TECHNOLOGY

摘要

The present invention provides an elastase inhibitory polypeptide comprising a C-terminal half of a human secretory leukocyte protease inhibitor (SLPI) and having an elastase inhibitory activity wherein an inhibitory activity of a trypsin-like serine protease does not excess 1/10 of an elastase inhibitory activity, and polypeptides having the above-mentioned biological activity wherein one or more than one amino acid is added, one or more than one amino acid is deleted and/or one or more than one amino acid is replaced. The present invention also provides a process for the production of the above-mentioned protein or other protein via a corresponding fused protein.