Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.
申请公布号
US6015688(A)
申请公布日期
2000.01.18
申请号
US19950483577
申请日期
1995.06.07
申请人
CONNAUGHT LABORATORIES LIMITED
发明人
LOOSMORE, SHEENA;HARKNESS, ROBIN;SCHRYVERS, ANTHONY;CHONG, PELE;GRAY-OWEN, SCOTT;YANG, YAN-PING;MURDIN, ANDREW;KLEIN, MICHEL