发明名称 |
Combined use of GnRH agonist and antagonist |
摘要 |
PCT No. PCT/JP97/01459 Sec. 371 Date Aug. 14, 1997 Sec. 102(e) Date Aug. 14, 1997 PCT Filed Apr. 25, 1997 PCT Pub. No. WO97/40846 PCT Pub. Date Nov. 6, 1997The present invention relates to a pharmaceutical luteinizing hormone releasing hormone agonist in combination with a luteinizing hormone releasing hormone antagonist. By using a luteinizing hormone releasing hormone agonist and a luteinizing hormone releasing hormone antagonist in combination, the transient exacerbation with elevation of serum testosterone and estrogen owing to the pituitary-gonadotropic action (acute action) manifested immediately following an initial dose of the luteinizing hormone releasing hormone agonist can be successfully obviated.
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申请公布号 |
US6015789(A) |
申请公布日期 |
2000.01.18 |
申请号 |
US19970894317 |
申请日期 |
1997.08.14 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
SUZUKI, NOBUHIRO;FURUYA, SHUICHI |
分类号 |
A61K38/09;(IPC1-7):A61K38/09;A61K31/505;A61K31/44 |
主分类号 |
A61K38/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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