17 beta -nitro-11 beta -arylisteroids and their derivatives having agonist or antagonist hormonal properties

摘要

The invention is directed to 11 beta -arylsteroids of formula II: wherein R1, R6, R8, R12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity and are useful in the treatment of fibroids, endometriosis, cervical ripening prior to delivery, hormone replacement therapy and in the control of fertility.