| 发明名称 |
HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODIES |
| 摘要 |
The invention relates to new humanized monoclonal antibodies deriving from murine anti-EGFR antibody 425 comprising an artificial modified consensus sequence at least of the FRs in the variable region of the heavy chain of human immunoglobulins. The invention relates, furthermore, to humanized and chimeric monoclonal antibodies which are binding to epitopes of the epidermal growth factor receptor (EGFR). The invention discloses the amino acid sequences of the responding antigen-binding site for this receptor. |
| 申请公布号 |
KR100240308(B1) |
申请公布日期 |
2000.01.15 |
| 申请号 |
KR19927002755 |
申请日期 |
1992.11.06 |
| 申请人 |
MERCK PATENT GMBH |
发明人 |
BENDIG, MARY M.;KETTLEBOROUGH, CATHERINE A.;SALDANHA, JOSE |
| 分类号 |
A61K39/395;A61K38/00;A61K49/04;A61K51/00;A61P35/00;A61P43/00;C07K14/00;C07K14/16;C07K14/485;C07K14/52;C07K14/705;C07K14/715;C07K16/00;C07K16/28;C07K19/00;C12N5/10;C12N15/09;C12N15/13;C12P21/08;C12R1/91;G01N33/53;G01N33/577;(IPC1-7):C07K14/00 |
主分类号 |
A61K39/395 |
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